Homemade Southern Chicken Spaghetti Casserole

Name: Homemade Southern Chicken Spaghetti Casserole
Prep time: 15 min
Cook time: 4 h
Total time: 4 h 15 min
Yield: 6 servings
Ingredients: 2 cups cooked chicken, shredded; 8 ounces spaghetti, uncooked; 2 cups zesty tomato sauce; 1 cup cream of mushroom soup; 1 cup shredded cheddar cheese; 1 cup shredded mozzarella cheese; 1 teaspoon Italian seasoning; Salt and pepper to taste

Highlighted under: Comfort Food

This comforting and creamy Southern Chicken Spaghetti Casserole brings the warmth of Southern flavors to your dinner table. Packed with tender chicken, zesty tomato sauce, and a blend of cheeses, this easy-to-make dish is a family favorite that’s perfect for weeknight dinners or potlucks. Simply toss everything together in your crockpot and let it do the work while you enjoy time with loved ones. A hearty, satisfying meal that combines classic Southern ingredients for an unforgettable taste.

Created by

Emma

Last updated on 2025-10-23T08:09:59.815Z

This dish is deeply rooted in Southern culinary traditions, offering a blend of flavors that evoke a sense of comfort and nostalgia.

A Taste of the South

Southern cuisine is known for its rich flavors and comforting textures, and this chicken spaghetti casserole encapsulates all that goodness. Combining tender chicken with zesty tomato sauce and smooth cream of mushroom soup creates a harmony of flavors that dance on your palate. It’s the kind of dish that invites everyone to gather around the table, making it perfect for family dinners or gatherings with friends.

In the South, meals are not just about nourishment; they’re about connection and togetherness. This casserole is an easy way to whip up a dish that feels homemade and heartfelt. Each ingredient comes together to tell a story of Southern hospitality, making every bite a reminder of warmth and love.

Effortless Preparation

One of the best things about this recipe is how effortlessly it comes together. With its straightforward steps, even novice cooks can impress their families without spending hours in the kitchen. All you need to do is shred the cooked chicken, combine your ingredients, and let the crockpot do its magic. It's a hassle-free way to enjoy a hearty meal on busy weeknights.

This simple preparation method means you can spend less time cooking and more time enjoying the company of your loved ones. Toss everything into the crockpot, set a timer, and go about your day. Whether you’re doing household chores or catching up with family, it allows for effortless multitasking while ensuring a delicious meal awaits you.

Customizable Comfort

One of the standout features of this casserole is its versatility. While the base recipe is a hit, you can easily adjust it to suit your family's tastes. Love a little heat? Add diced jalapeños or red pepper flakes for extra spice. Want more veggies? Toss in bell peppers, onions, or even spinach for added nutrition and flavor. This dish can easily adapt to your family’s palate.

You can also experiment with different types of cheese. If cheddar and mozzarella aren’t your favorites, try pepper jack for a kick or gouda for a smoky taste. This customizable element not only makes the dish more exciting but also allows you to make it again and again, each time with a new twist.

Ingredients

Main Ingredients

2 cups cooked chicken, shredded
8 ounces spaghetti, uncooked
2 cups zesty tomato sauce
1 cup cream of mushroom soup
1 cup shredded cheddar cheese
1 cup shredded mozzarella cheese
1 teaspoon Italian seasoning
Salt and pepper to taste

Combine all ingredients in your crockpot for a delicious meal!

Instructions

Prepare the Ingredients

Shred the cooked chicken and set aside. In a large bowl, combine the tomato sauce, cream of mushroom soup, and seasonings.

Combine Ingredients in Crockpot

Layer the uncooked spaghetti, shredded chicken, and sauce mixture in the crockpot. Mix well.

Cook the Casserole

Cover and cook on low for 4 hours until pasta is tender. Stir in the cheeses before serving.

Serve hot and enjoy with your favorite side dishes!

Tips for Success

To ensure your chicken spaghetti casserole turns out perfectly every time, it's essential to start with quality ingredients. Use fresh, shredded chicken for the best flavor and texture. If using leftovers, ensure they are finely shredded so they blend well with the other components.

Another tip for success is to stir the casserole halfway through cooking. This helps ensure even cooking and prevents the pasta from clumping together. If you find the mixture too thick, feel free to add a splash of broth or water to reach your desired consistency.

Serving Suggestions

This chicken spaghetti casserole is delightful on its own, but pairing it with a side salad or garlic bread can elevate the meal. A crunchy garden salad with your favorite dressing adds a fresh contrast to the creamy casserole, making it a well-rounded dinner.

Consider topping the casserole with fresh herbs like parsley or basil before serving for a pop of color and fresh flavor. This simple step adds a touch of gourmet appeal to your comforting dish and impresses your family or guests with minimal effort.

Storage and Leftovers

If you’re fortunate enough to have leftovers, they store beautifully in the refrigerator. Just place the casserole in an airtight container for up to three days. Reheating can be done in the oven or microwave, making it an easy meal option for busy days ahead.

For longer storage, consider freezing your casserole. Portion it out into freezer-safe containers and use it within three months. This makes for an excellent make-ahead meal that you can enjoy anytime you need a comforting dinner without the hassle of cooking from scratch.

Questions About Recipes

→ Can I use leftover turkey instead of chicken?

Absolutely! Leftover turkey works wonderfully in this recipe.

→ How can I make this dish spicier?

Add red pepper flakes or diced jalapeños to the sauce for an extra kick.